Development and evaluation of controlled porosity osmotic pump tablets for zidovudine and lamivudine combination. Controlledporosity osmotic pump tabletsan overview ajay. Controlled porosity osmotic pump cpop figure 9 represents the controlled porosity osmotic pump cpop. The osmotic drug delivery systems suitable for oral administration typically consist of a compressed tablet core that is coated with a semipermeable membrane that has an oriice drilled on it by means of a laser beam or mechanical. When controlled porosity osmotic pump tablets placed in biological system of fluid low levels of water soluble additives are leached from polymer materials which form sponge like structure in the controlled porosity walls. Controlled porosity osmotic pumpbased controlled release systems of. There is achance of dose dumping if the coating process is not well controlled. The rate of drug release for the adhesive diffusion control system is denoted as follows. The aim of the current study was to design a controlled porosity osmotic pump cpopbased drug delivery system for controlled release of an nsaid agent. Controlled porosity osmotic pumpbased controlled release systems of pseudoephedrine. L oros hard cap, l oros soft cap and delayed liquid bolus delivery system, telescopic capsule, 23 oros ct, 24 sandwiched osmotic. Controlled porosity osmotic pump cpop controlled porosity osmotic pump is an osmotic tablet in which membrane contains water soluble leachable pore forming agents.
Pdf preparation and evaluation of osmotic pump systems. Formulation and evaluation of controlled porosity osmotic. Controlled porosity osmotic pump cpop based drug delivery system contains active ingredient, osmogens, semi permeable membrane. Some of the investigators have also studied the role of parameters like coating, release retardants etc. The instant invention is directed to an osmotic pump, for the controlled release of diltiazem lmalate to an environment of use, said pump comprising. Formulation development and evaluation of controlled. Design and development of controlled porosity osmotic tablets. Evolution of osmotically controlledrelease systems figure 1. Recent advances include various specific types of osmotic pump systems such as controlled porosity osmotic pump 20 cpop, osmotic bursting osmotic pump 21 obop, liquid orosliquid oral osmotic system 22 e. Osmotic pressure controlled drug delivery system authorstream. Elementary osmotic pump the elementary osmotic pump is a new delivery system for drugs. Controlledporosity osmotic pump tabletsan overview ajay babu. Formulation and optimization of controlled porosity osmotic pump tablets of zidovudine using mannitol as osmogen for the treatment of aids chinmayakeshari sahoo1, surepalli ram mohan rao2, muvvala sudhakar3 1ph. Pdf mechanism of release from pellets coated with an.
Patel h, patel ud, kadikar h, bhimani b, daslaniya d, patel g. Osmotic tablet cores containing various ratios of ketoprofen and. The antiinflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase2 cox2, an enzyme involved in prostaglandin synthesis via the arachidonic. Poorly watersoluble drug with phdependent solubility such as gliclazide glz offers challenges in the controlled release formulation because of low dissolution rate and poor bioavailability. Journal of controlled release, 1 1985 26982 eisevier science publishers b. Then, controlled porosity osmotic pump cpop tablet of gliclazide was designed to deliver drug in a controlled manner up to 16 h.
It is difficult to formulate osmotic tablet of metoprolol succinate which. The coating of semi permeable membrane is done by a suitable coating method. D scholar, pharmaceutics department, faculty of pharmacy, university college of technology,osmania university,hyderabad,telangana500007, india. Metoprolol succinate is very high soluble drug, so complete drug release obtained very fast. Keywords osmotic pump, controlled porosity osmotic pump tablet, semipermeable membrane, osmogent, leachable pore formers. D scholar, pharmaceutics department, faculty of pharmacy, university college of technology,osmania university,hyderabad,telangana 500007. In the present investigation, controlled porosity osmotic pump cpop system of glipizide gz was developed since preparation of cpop is simple. Rose and nelson developed an implantable pump in 1955. Nov 06, 1990 the instant invention is directed to an osmotic pump comprising.
Pharmaceutical controlled release drug delivery systems. In majority of the cases, osmotic systems have a preformed passageway in the membrane from where the drug release takes place. Development of pushpull osmotic pump tablets for a. So it is difficult to formulate osmotic tablet of carvedilol phosphate which gives drug release up to 24 hr at zero order. In this study, osmotic drug delivery matrix tablets of losartan potassium were developed. The first elementary osmotic pump, invented by theeuwes, consists of a single compartment. Such systems in the form of tablets are intended for achieving controlled release of said drugs over 1224 hours for the treatment of various chronic therepeutic conditions. Optimal design and numerical optimization technique was applied to find out the best formulation. Optimization and development of swellable controlled. Controlled porosity osmotic tablet of carvedilol phosphate prepared and evaluated in this study. Review on controlled porosity osmotic pump tablets and its basic. Osmosis refers to the process of movement of solvent from lower concentration of solute towards higher concentration of solute across a semipermeable membrane.
Therefore, there was a need to modulate the solubility of the drug using suitable. Apr 14, 2003 a controlled porosity osmotic pump based drug delivery system has been described in this study. Formulation and evaluation of losartan potassium osmotic. Release was also studied as a function of the osmotic pressure in the. Development and evaluation of controlled porosity osmotic. Controlled porosity osmotic pumps were introduced for the first time in 1985 which necessitates the removal of the mechanically drilled orifice and a patent was granted for the same in the year 1986. Coating formulation design and process control are the two most commonly. Evolution of osmotically controlled release systems figure 1. Although controlled porosity osmotic pump tablet could be prepared simply, they were usually applicable for soluble drugs. D scholar, department of pharmaceutics, faculty of pharmacy, university college of technology. Unlike the elementary osmotic pump eop which consists of an osmotic core with the drug surrounded by a semipermeable membrane drilled with a delivery orifice, controlled porosity of the membrane is accomplished by the use of different channeling. A a core which comprises a therapeutically effective amount of diltiazem lmalate and an effective buffering amount of sodium bitartrate surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6. A novel controlled porosity osmotic pump system for sodium ferulate lili he, tao gong, dong zhao, zhirong zhang, lili li received mar ch 3, 2006, accepte d april 10, 2006.
The aim of the current study was to design a controlled porosity osmotic pump cpopbased drug delivery system for controlled release of an nsaid agent, ketorolac tromethamine, which is expected to improve patient compliance due to reduced frequency. Asian journal of pharmaceutics octdec 2016 10 4 287 formulation and optimization of controlled porosity osmotic pump tablet for oral administration of glipizide s. Eudragit l100ibuprofen and eudragit l100naproxen particles with. International journal of chemtech research formulation and. It is a propionic acid derivative and is a nonsteroidal antiinflammatory agent nsaia with analgesic and antipyretic properties. The current ca 2019 market of transdermal patches in the us and. Formulation and optimization of controlled porosity osmotic pump tablets of zidovudine using mannitol as osmogen for the treatment of aids chinmayakeshari sahoo 1, surepalli ram mohan rao 2, muvvala sudhakar 3 1 ph. A a core which comprises a therapeutically effective amount of diltiazem lmalate and an effective buffering amount of sodium bitartrate surrounded by b a rate controlling water insoluble wall, having a fluid. The porous osmotic pump tablets were designed using d.
However, the drawback of this potentially useful hypoglycemic agent is that it is highly hydrophobic and practically insoluble in water. Poorly watersoluble drug with phdependent solubility such as gliclazide glz offers challenges in the controlledrelease formulation because of low dissolution rate and poor bioavailability. Formulation and optimization of controlled porosity osmotic. Osmotic agent sodium chloride and pore former peg 400 was considered as independent variables. Formulation and evaluation of controlled porosity osmotic pump for. Controlled porosity osmotic pump tablets thesis writing.
Formulation and evaluation of oral controlled release osmotic. Formulation and optimization of controlled porosity. The controlled porosity osmotic pump sciencedirect. Applied to pharmaceutics 2014, microneedle patches. Development of pushpull osmotic pump tablets for a slightly water soluble drug piyush patel, shahrzad missaghi, sandip b.
Formulation aspects in development of controlled porosity. Formulation and evaluation of controlled porosity osmotic pump for oral delivery of ketorolac abstract background. Captopril, osmotic tablets, controlled release design and development of controlled porosity osmotic tablets of captopril article history. Optimization and development of swellable controlled porosity.
Preparation of controlled porosity osmotic pump tablets for. Figure 1 is courtesy of the author osmotically controlled oral drugdelivery systems have come a long way. Development of controlled porosity osmotic pump of metoprolol. The instant invention is directed to an osmotic pump comprising. Osmotic agent sodium chloride and pore former peg 400 was considered as. Development and evaluation of extended release formulations of isosorbide mononitrate based on osmotic technology. The coating composition of cpop includes pore forming. Preparation and evaluation of ketoprofen as dermal spray film. A system that can deliver drug at a controlled rate is very important for the treatment of various chronic diseases such as diabetes, asthma, and heart disease. A water permeation characteristics of a semi permeable membrane surrounding the formulating agent b osmotic properties of the formulation 4102011 vikramjit singh. Osmotic drug delivery uses the osmotic pressure for controlled delivery of drugs by using osmogens for upto 10 16 hrs. The controlled porosity osmotic pump has been developed via incorporation of leachable watersoluble small molecules, such as sodium chloride, potassium chloride, urea, and sucrose etc.
They are the most reliable controlled drug delivery systems and could be employed as oral drug delivery systems. Dec 17, 2015 the present study aimed to prepare, optimize, and evaluate tapentadol hydrochloride controlled porosity osmotic pump cpop and to achieve the drug release at nearly zeroorder. A modified twolayered, pushpull osmotic system was developed by using the basic designs of various oral osmotic pumps, such as controlled porosity osmotic pump cpop, elementary osmotic pump eop and pushpull osmotic pump. July september 9 the unique feature of semipermeable membrane utilized for an osmotic pump is that it permits. Oral osmotic systems in which the delivery passage way is formed in situ are described in us patent no. Design and development of controlled porosity osmotic. It delivers the agent by an osmotic process at a controlled rate. Osmotic drug delivery system as a part of modified release. Asian journal of research in chemistry and pharmaceutical. A boxbehnken experimental design was applied to optimize the parameters for cpop. Unlike the elementary osmotic pump eop which consists of an osmotic core with the drug surrounded by a semi permeable membrane drilled with a delivery orifice, controlled porosity of.
In this paper, we pioneered application of ann for the optimization of the formulation composition of the controlled porosity osmotic pump tablet 7, a practice and learning that may potentially be of benefit to the industry. Osmotic drug delivery using swellablecore technology. The controlled porosity osmotic pump does not require a delivery orifice for drug release, hence eliminating the need for complicated laserdrilling procedures 18, 19. Osmotic devices are the most promising strategy based systems for controlled drug delivery. Formulation and evaluation of oral controlled release. Disouza3 1department of pharmaceutics, sant gajanan maharaj college of pharmacy, mahagaon, gadhinglaj.
The desired release profile was obtained by optimizing polymer concentration, channeling agent level, and plasticizer concentration. The details of various marketed products of various osmotic pump drug delivery systems are furnished in table 2. Osmotic pump controlled porosity cpop system have been disclosed for drugs that have varying solubility characteristics such as diclofenac sodium, pramipexole and nifedipine. Apr 29, 2012 a modified twolayered, pushpull osmotic system was developed by using the basic designs of various oral osmotic pumps, such as controlled porosity osmotic pump cpop, elementary osmotic pump eop and pushpull osmotic pump ppop. The present study aimed to prepare, optimize, and evaluate tapentadol hydrochloride controlled porosity osmotic pump cpop and to achieve the drug release at nearly zeroorder. Pharmaceutics free fulltext an update of moisture barrier. Development of controlled porosity osmotic pump of.
Rajabisiahboomi1over the last decade, there has been increasing interest in the development of oral osmotic devices in. It is an osmotic tablet wherein the delivery orifices holes are formed in situ through leaching of water soluble poreforming agents incorporated in semipermeable membrane spm e. Development and characterization aspects of elementary osmotic pump tablets are explained this book. Received 25 aug 20 accepted 10 sept 20 available online sept 20 as dose, absorption rate constant, elimination rate constant, metabolic properties. Jul 25, 1989 the instant invention is directed to a multiparticulate osmotic pump, for the controlled release of a pharmaceutically active agent to an environment of use, said pump comprising. Development of a marketed formulation of push pull osmotic pump of nifedipine was named as procardia xl by pfizer inc in 1989 which became the. This device is known as swellable controlled porosity osmotic pump scpop. Ketoprofen is only found in individuals that have used or taken this drug. A schematic diagram of the controlled porosity osmotic pump can be seen in fig. Asian journal of research in chemistry and pharmaceutical sciences. Illustration of the a elementary osmotic pump and the b pushpull osmotic pump. Controlled porosity osmotic pump based controlled release system of pseudoephedrinei cellulose acetate as a semipermeable membrane. Controlled porosity solubility modulated osmotic pump tablets. Such delivery systems are based on the principle of osmosis.
The present study was aimed towards the development of extended release formulations of losartan potassium based on osmotic technology. Chinmaya keshari sahoo 1, surepalli ram mohan rao 2, muvvala sudhakar 3. A boxbehnken experimental design was applied to optimize. When these systems are exposed to water, low levels of water soluble additive is leached from polymeric material i. Controlledporosity osmotic pump tabletsan overview.
The cpop was prepared by the coating of polymers eudragit rspo and rlpo on a directly compressed core tablet. Review on controlled porosity osmotic pump tablets and its. Controlled porosity osmotic pump cpop drug delivery system is a dosage form which provides controlled release of drug. The developed formulation was optimized for type and level of. Controlled porosity solubility modulated osmotic pump. A controlled porosity osmotic pump comprising a tablet coated with ethyl cellulose as a semipermeable membrane containing different levels of channeling agent has been developed for ketorolac tromethamine.
A controlled porosity osmotic pumpbased drug delivery system has been described in this study. Controlled porosity osmotic pumpbased controlled release system of pseudoephedrinei cellulose acetate as a semipermeable membrane. A at least one active agent surrounded by b a rate controlling water insoluble wall, having a fluid permeability of 6. Vavia et al 19 studied a controlled porosity osmotic pump based drug delivery system. Controlled porosity osmotic pump tablet cpop system was designed to deliver nifedipine np and metoprolol mp in a controlled manner up to 12 h. Received 25 aug 20 accepted 10 sept 20 available online sept 20 as dose, absorption rate constant, elimination rate constant, metabolic properties, for correspondence. The instant invention is directed to a multiparticulate osmotic pump, for the controlled release of a pharmaceutically active agent to an environment of use, said pump comprising. Development and evaluation of a oncedaily controlled. Studied a controlled porosity osmotic pumpbased drug delivery system. Preparation of controlled porosity osmotic pump tablets. Controlled porosity osmotic tablet of metoprolol succinate prepared and evaluated in this study.
1352 1159 340 155 1008 1019 1188 116 1125 52 6 592 640 430 1287 448 1340 1485 1016 137 535 1083 749 888 887 648 500 511 1335 1425 433 1382 979